C-type lectin

Lectin C-type domain
PDB 1jzn EBI.jpg
Pentameric structure of rattlesnake venom lectin which is a galactose binding lectin.[1] [2]
Symbol Lectin_C
Pfam PF00059
InterPro IPR001304
CDD cd00037
Membranome 52

A C-type lectin (CLEC) is a type of carbohydrate-binding protein domain known as a lectin.[3] The C-type designation is from their requirement for calcium for binding.[4] Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis.[5][6]

Classification [ edit ]

Drickamer et al. classified C-type lectins into 7 subgroups (I to VII) based on the order of the various protein domains in each protein.[7] This classification was subsequently updated in 2002, leading to seven additional groups (VIII to XIV).[8] Most recently, three further subgroups were added (XV to XVII).[3]

Group Name Associated domains
I Lecticans EGF, Sushi, Ig and Link domains
II Asialoglycoprotein and DC receptors None
III Collectins None
IV Selectins Sushi and EGF domains
V NK - cell receptors None
VI Multi-CTLD endocytic receptors FnII and Ricin domains
VII Reg group None
VIII Chondrolectin, Layilin None
IX Tetranectin None
X Polycystin WSC, REJ, PKD domains
XI Attractin (ATRN) PSI, EGF and CUB domains
XII Eosinophil major basic protein (EMBP) None
XIV Thrombomodulin, CD93, CD248, CLEC14A EGF domains [9]
XV Bimlec None
XVI SEEC SCP and EGF domains
XVII CBCP/Frem1/QBRICK CSPG repeats and CalX-beta domains

CLECs include:

The "NK Cell lectin-like receptors" are a very closely related group:[10]

Additional proteins containing this domain include:

References [ edit ]

  1. ^ Walker JR, Nagar B, Young NM, Hirama T, Rini JM (April 2004). "X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure". Biochemistry. 43 (13): 3783–92. doi:10.1021/bi035871a. PMID 15049685.
  2. ^ Mahla RS, Reddy MC, Prasad DV, Kumar H (September 2013). "Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology". Frontiers in Immunology. 4: 248. doi:10.3389/fimmu.2013.00248. PMC 3759294. PMID 24032031.
  3. ^ a b Zelensky AN, Gready JE (December 2005). "The C-type lectin-like domain superfamily". FEBS J. 272 (24): 6179–217. doi:10.1111/j.1742-4658.2005.05031.x. PMID 16336259.
  4. ^ C-Type+Lectin at the US National Library of Medicine Medical Subject Headings (MeSH)
  5. ^ Drickamer K (October 1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765.
  6. ^ Cambi A, Figdor C (May 2009). "Necrosis: C-type lectins sense cell death". Curr. Biol. 19 (9): R375–8. doi:10.1016/j.cub.2009.03.032. PMID 19439262.
  7. ^ Drickamer K (1993). "Evolution of Ca(2+)-dependent animal lectins". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 45: 207–32. doi:10.1016/S0079-6603(08)60870-3. ISBN 978-0-12-540045-9. PMID 8341801.
  8. ^ Drickamer K, Fadden AJ (2002). "Genomic analysis of C-type lectins". Biochem. Soc. Symp. (69): 59–72. PMID 12655774.
  9. ^ "C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation". FEBS Journal. PMID 31287944.
  10. ^ NK+Cell+Lectin-Like+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

External links [ edit ]

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